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人类亚急性海绵状脑病向小型啮齿动物的实验性传播。IV. 来自典型格斯特曼-施特劳斯勒-谢inker病病例的阳性传播。

Experimental transmission of human subacute spongiform encephalopathy to small rodents. IV. Positive transmission from a typical case of Gerstmann-Sträussler-Scheinker's disease.

作者信息

Tateishi J, Sato Y, Nagara H, Boellaard J W

出版信息

Acta Neuropathol. 1984;64(1):85-8. doi: 10.1007/BF00695613.

DOI:10.1007/BF00695613
PMID:6382907
Abstract

Spongiform encephalopathy was transmitted to mice from a patient belonging to the "Sch" family with Gerstmann-Sträussler-Scheinker's disease (GSS). Incubation periods in the first passage were much shorter than those in mice infected with Creutzfeldt-Jakob disease. Clinical and pathologic findings of mice infected with both diseases were almost identical. This is the first successful transmission from a typical GSS case without severe spongiform change which suggests the possible transmissible nature of this disorder.

摘要

海绵状脑病从一名患有格斯特曼-施特劳斯勒-谢inker病（GSS）的“Sch”家族患者传播给了小鼠。首次传代时的潜伏期比感染克雅氏病的小鼠短得多。感染这两种疾病的小鼠的临床和病理表现几乎相同。这是首次成功地从一个没有严重海绵状变化的典型GSS病例进行传播，这表明这种疾病可能具有传染性。

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[Morbus Gerstmann-Sträussler-Scheinker. The Sch. family-a report of three cases (author's transl)].[格斯特曼-施特劳斯勒-申克病。施氏家族——三例报告（作者译）]
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Sträussler's disease.施特劳斯勒病
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