Sato Y, Ohta M, Tateishi J
Acta Neuropathol. 1980;51(2):135-40. doi: 10.1007/BF00690455.
Light and electron microscopic findings of spongy state in four species of small rodents, viz, mice, rats, Mongolian gerbils, and guinea pigs, are described. The spongy state existed in both gray and white matter; its intensity varied in each species, and in the gray matter corresponded to vacuoles within the neuropil. They were of two types; one was the true vacuoles within neurites, and the other was markedly swollen cell processes, some of which were also identified as neurites. In the white matter, the spongy state corresponded mainly to distension of the myelin sheaths, due to splitting of the major dense line or swelling of the inner loop, and partly to intra-axonal vacuoles. In mice before appearance of clinical symptoms, the vacuolation occurred first in the cerebral white matter 5 weeks after inoculation and in the cerebral cortex at 7 weeks. The occurrence and development of the vacuoles are discussed.
描述了四种小型啮齿动物（即小鼠、大鼠、蒙古沙鼠和豚鼠）海绵状状态的光镜和电镜观察结果。海绵状状态存在于灰质和白质中；其强度在每个物种中有所不同，在灰质中与神经毡内的空泡相对应。空泡有两种类型；一种是神经突内的真正空泡，另一种是明显肿胀的细胞突起，其中一些也被鉴定为神经突。在白质中，海绵状状态主要对应于髓鞘的扩张，这是由于主致密线的分裂或内环的肿胀，部分对应于轴突内空泡。在出现临床症状前的小鼠中，接种后5周脑白质首先出现空泡化，7周时大脑皮质出现空泡化。对空泡的发生和发展进行了讨论。
