Tateishi J, Sato Y, Koga M, Doi H, Ohta M
Acta Neuropathol. 1980;51(2):127-34. doi: 10.1007/BF00690454.
Experimental transmission of subacute spongiform encephalopathy from three human cases to small rodents is reported. The first case with atypical CJD with spongiform change, kuru plaques, and leukomalacia was transmitted directly to mice, rats, and guinea pigs and indirectly to hamsters and Mongolian gerbils through rats. From two other typical SSE cases the disease was also successfully transmitted; from he second case to mice and rats, and from the third case to guinea pigs. Brain showed the highest infectivity; the spleen, liver, blood, and cerebrospinal fluid of diseased animals were also infective. Intracerebral inoculation was the route for the fastest transmission, followed by intrathecal, intraperitoneal, submucosal, and subcutaneous routes. The incubation periods and clinical features were characteristic in each inoculated species and did not vary within several passages, except for the shortening of incubation period from the first to the second passage. Histologically, a marked spongy state and proliferation of astrocytes were observed in all diseased animals, though the distribution of the lesion was peculiar to each species. The severe lesion in the white matter in mice was similar to that seen in mice inoculated with scrapie and also to that seen in the first case.
据报道，已将3例人类亚急性海绵状脑病传染给小型啮齿动物。首例具有海绵状改变、库鲁斑和脑白质软化的非典型克雅氏病直接传染给小鼠、大鼠和豚鼠，并通过大鼠间接传染给仓鼠和蒙古沙鼠。另外两例典型的海绵状脑病也成功实现了传染；第二例传染给小鼠和大鼠，第三例传染给豚鼠。脑的传染性最强；患病动物的脾脏、肝脏、血液和脑脊液也具有传染性。脑内接种是传播最快的途径，其次是鞘内、腹腔内、粘膜下和皮下途径。每种接种动物的潜伏期和临床特征都具有特异性，并且在传代几次内没有变化，只是从第一代到第二代潜伏期有所缩短。组织学上，在所有患病动物中均观察到明显的海绵状状态和星形胶质细胞增生，尽管病变分布因物种而异。小鼠白质中的严重病变与接种羊瘙痒病的小鼠以及首例病例中的病变相似。
