Boer P, van Leersum L, Hené R J, Mees E J
Am J Kidney Dis. 1984 Sep;4(2):118-22. doi: 10.1016/s0272-6386(84)80058-x.
Plasma oxalate was measured with use of the enzyme oxalate oxidase (EC 1.2.3.4; normal values 3.3 +/- 1.5 mumol/L, n = 24) in 50 patients with different degrees of renal failure. The following mean concentrations +/- SD (in mumol/L) were found: for glomerular diseases, 12.7 +/- 7.8 (n = 21); tubular diseases, 20.4 +/- 14.0 (n = 16); chronic renal failure before dialysis, 32.5 +/- 13.5, and after dialysis, 17.8 +/- 3.8 (n = 10); and primary hyperoxalemia, 72.2 +/- 14.5 14.5 (n = 2). The course of plasma oxalate was followed in one of these two patients after renal transplantation and in a patient recovering from acute tubular necrosis. No significant differences were found between patients with glomerular and tubular disorders. Overall, plasma oxalate was correlated with plasma creatinine in patients with glomerular and tubular diseases and dialysis patients (r = .84, P less than .001). Patients with primary hyperoxalemia had values outside the 95% confidence area of the regression line. It is concluded that the values obtained with this method, although probably still tending to overestimate the true oxalate concentration to some extent, provide reliable information about relative differences in plasma oxalate levels. In patients with terminal renal failure, plasma oxalate sometimes rises to levels at which deposition of calcium oxalate in tissues can occur.
采用草酸氧化酶（EC 1.2.3.4；正常值3.3±1.5μmol/L，n = 24）对50例不同程度肾衰竭患者的血浆草酸进行了测定。得到以下平均浓度±标准差（单位为μmol/L）：肾小球疾病患者为12.7±7.8（n = 21）；肾小管疾病患者为20.4±14.0（n = 16）；透析前慢性肾衰竭患者为32.5±13.5，透析后为17.8±3.8（n = 10）；原发性高草酸血症患者为72.2±14.5（n = 2）。对其中两名原发性高草酸血症患者中的一名进行了肾移植后以及一名急性肾小管坏死恢复患者的血浆草酸变化过程监测。肾小球疾病和肾小管疾病患者之间未发现显著差异。总体而言，肾小球疾病、肾小管疾病患者以及透析患者的血浆草酸与血浆肌酐相关（r = 0.84，P < 0.001）。原发性高草酸血症患者的值超出了回归线的95%置信区间。结论是，尽管用该方法获得的值可能仍在一定程度上倾向于高估真实的草酸浓度，但能提供关于血浆草酸水平相对差异的可靠信息。在终末期肾衰竭患者中，血浆草酸有时会升至可导致草酸钙在组织中沉积的水平。
