吸入暴露方法学。
Inhalation exposure methodology.
作者信息
Phalen R F, Mannix R C, Drew R T
出版信息
Environ Health Perspect. 1984 Jun;56:23-34. doi: 10.1289/ehp.845623.
Abstract
Modern man is being confronted with an ever-increasing inventory of potentially toxic airborne substances. Exposures to these atmospheric contaminants occur in residential and commercial settings, as well as in the workplace. In order to study the toxicity of such materials, a special technology relating to inhalation exposure systems has evolved. The purpose of this paper is to provide a description of the techniques which are used in exposing laboratory subjects to airborne particles and gases. The various modes of inhalation exposure (whole body, head only, nose or mouth only, etc.) are described at length, including the advantages and disadvantages inherent to each mode. Numerous literature citations are included for further reading. Among the topics briefly discussed are the selection of appropriate animal species for toxicological testing, and the types of inhalation studies performed (acute, chronic, etc.).
摘要
现代人正面临着越来越多潜在有毒空气传播物质。接触这些大气污染物的情况发生在住宅、商业场所及工作场所。为了研究此类物质的毒性，一种与吸入暴露系统相关的特殊技术应运而生。本文旨在描述用于使实验室对象接触空气传播颗粒和气体的技术。详细介绍了各种吸入暴露模式（全身、仅头部、仅鼻子或嘴巴等），包括每种模式固有的优缺点。文中包含大量文献引用以供进一步阅读。简要讨论的主题包括毒理学测试中合适动物物种的选择以及所进行的吸入研究类型（急性、慢性等）。
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本文引用的文献
1
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J Hyg (Lond). 1952 Mar;50(1):53-68. doi: 10.1017/s0022172400019422.
2
A CANINE INHALATION EXPOSURE APPARATUS UTILIZING A WHOLE BODY PLETHYSMOGRAPH.一种利用全身体积描记器的犬类吸入暴露装置。
Health Phys. 1964 Dec;10:1077-89. doi: 10.1097/00004032-196412000-00028.
3
Chronic tracheostomy in dogs.犬的慢性气管造口术
J Appl Physiol. 1963 Mar;18:439-40. doi: 10.1152/jappl.1963.18.2.439.
4
SO-2 effects on the respiratory system in dogs; changes in mechanical beahvior at different levels of the respiratory system during acute exposure to the gas.二氧化硫对犬呼吸系统的影响；急性暴露于该气体期间呼吸系统不同水平的机械行为变化。
Arch Environ Health. 1965 Nov;11(5):624-34. doi: 10.1080/00039896.1965.10664271.
5
A face mask and mouthpiece for respiratory studies in unanesthetized Beagle dogs.用于未麻醉比格犬呼吸研究的面罩和咬嘴。
J Appl Physiol. 1969 Jul;27(1):104-5. doi: 10.1152/jappl.1969.27.1.104.
6
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