Arnold W, Pfaltz R, Altermatt H J
Acta Otolaryngol. 1985 Mar-Apr;99(3-4):437-44. doi: 10.3109/00016488509108935.
In healthy human temporal bones, immunoglobulins (IgG, IgA) and the secretory component are demonstrated by two immunohistochemical methods in epithelial cells and in the lumen of the endolymphatic sac. The normal human inner ear does not otherwise show any localization of immunoglobulins. By means of indirect immunofluorescence, antibodies against healthy inner ear tissue were found in the serum of 15 out of 21 patients with double-sided progressive or fluctuating sensorineural hearing loss of undefined etiology. In 2 cases of Cogan's syndrome, it was also possible to demonstrate serum antibodies against epithelial structures of the cornea. The lymphocyte mitogen stimulation test performed with the fresh blood of 5 patients with positive detection of serum antibodies against healthy inner ear tissue was negative.
在健康人颞骨中，通过两种免疫组织化学方法在上皮细胞和内淋巴囊腔内证实了免疫球蛋白（IgG、IgA）和分泌成分。正常人类内耳在其他方面未显示免疫球蛋白的任何定位。通过间接免疫荧光法，在21例病因不明的双侧进行性或波动性感音神经性听力损失患者中，有15例患者的血清中发现了针对健康内耳组织的抗体。在2例科根综合征患者中，也能够证实血清中存在针对角膜上皮结构的抗体。对5例血清中检测到针对健康内耳组织抗体呈阳性的患者的新鲜血液进行淋巴细胞有丝分裂原刺激试验，结果为阴性。
