Buijs W, van der Gen A, Mohn G R, Breimer D D
Mutat Res. 1984 Sep;141(1):11-4. doi: 10.1016/0165-7992(84)90029-0.
A series of 18 alpha, omega-dihalogenoalkanes (kappa(CH2)n kappa with n = 1-6 and kappa = Cl, Br, I) was tested for direct mutagenic activity in Salmonella strains TA1530, TA1535 and TA100 using spot-test procedures. The results indicate that the mutagenic behaviour of these compounds is strongly dependent upon the carbon chain length as well as the type of halogen involved. This behaviour correlates with the leaving group ability and the degree of neighbouring group participation in nucleophilic displacement reactions of the different halogen atoms.
使用点试验程序，对一系列18种α,ω-二卤代烷烃（κ(CH2)nκ，其中n = 1 - 6且κ = Cl、Br、I）在沙门氏菌菌株TA1530、TA1535和TA100中进行直接诱变活性测试。结果表明，这些化合物的诱变行为强烈依赖于碳链长度以及所涉及的卤素类型。这种行为与离去基团能力以及不同卤素原子在亲核取代反应中的邻基参与程度相关。
