Ratpan F, Plaumann H
Corporate Research and Development, Polysar Limited, Sarnia, Ontario, Canada.
Environ Mol Mutagen. 1988;12(2):253-9. doi: 10.1002/em.2860120211.
1,2,3-Tribromopropane, 1,2,3-trichloropropane, and 1,2-dibromo-3-chloropropane are mutagenic in strains TA1535 and TA100 of Salmonella typhimurium, but only in the presence of rat liver S9 mix. This requirement for metabolic activation was unexpected for an alkyl halide and thus suggested the metabolic formation of the 2-keto derivatives (di-haloacetone). The 2-methyl derivatives of the halopropane compounds did not induce a doubling of revertants compared to controls. It was demonstrated that none of these compounds is converted into a secondary material that could be determined as structurally different by gas chromatography. These observations suggest that lack of mutagenicity of the methylated compounds is a manifestation of a steric effect.
1,2,3 - 三溴丙烷、1,2,3 - 三氯丙烷和1,2 - 二溴 - 3 - 氯丙烷对鼠伤寒沙门氏菌TA1535和TA100菌株具有致突变性，但仅在存在大鼠肝脏S9混合液的情况下。对于卤代烷而言，这种对代谢活化的需求出人意料，因此表明会代谢形成2 - 酮衍生物（二卤代丙酮）。与对照相比，卤丙烷化合物的2 - 甲基衍生物并未诱导回复突变体数量翻倍。结果表明，这些化合物均未转化为可通过气相色谱法确定其结构不同的次生物质。这些观察结果表明，甲基化化合物缺乏致突变性是空间效应的一种表现。
