Molenaar C M, Woudt L P, Jansen A E, Mager W H, Planta R J, Donovan D M, Pearson N J
Nucleic Acids Res. 1984 Oct 11;12(19):7345-58. doi: 10.1093/nar/12.19.7345.
The genes encoding yeast ribosomal proteins rp28 and S16A are linked and occur duplicated in the yeast genome. In both gene pairs the genes are approximately 600 bp apart and are both transcribed in the same direction. Both ribosomal protein genes resemble other ribosomal protein genes studied so far in many structural aspects. The genes are interrupted by an intron near the 5'-end of their coding sequence. In addition the flanking regions contain several conserved sequence elements, which may function in transcription initiation and termination. In agreement with findings concerning other cloned yeast ribosomal protein genes, upstream homology blocks occur that may be involved in coordinate control of ribosomal protein gene transcription. The complete pattern of conserved and diverged sequences between the two duplicate gene pairs is presented.
编码酵母核糖体蛋白rp28和S16A的基因是连锁的，并且在酵母基因组中呈重复出现。在这两个基因对中，基因之间的距离约为600 bp，且转录方向相同。这两个核糖体蛋白基因在许多结构方面与迄今为止研究的其他核糖体蛋白基因相似。这些基因在其编码序列的5'端附近被一个内含子中断。此外，侧翼区域包含几个保守的序列元件，它们可能在转录起始和终止中发挥作用。与其他克隆的酵母核糖体蛋白基因的研究结果一致，存在上游同源性模块，可能参与核糖体蛋白基因转录的协调控制。本文展示了两个重复基因对之间保守和差异序列的完整模式。
