Winther B, Brofeldt S, Grønborg H, Mygind N, Pedersen M, Vejlsgaard R
Acta Otolaryngol. 1984 Sep-Oct;98(3-4):315-20. doi: 10.3109/00016488409107569.
It was the purpose of this study to examine whether the number of bacteria in the nose and nasopharynx changes during a common cold. Samples for bacteriological culture were taken from the nasal cavity of 29 and from the nasopharynx of 26 adult patients with naturally acquired colds. The bacteriological samples were taken on days 2, 4, 8 16, 32 and 64 after the first nasal symptoms. The results showed that there were few pathogenic bacteria in the nasal cavity and nasopharynx. There was no tendency to an increase in the number of positive cultures during the cold, although most patients had macroscopically purulent discharge on days 3-5. In conclusion, the study indicates that during an uncomplicated common cold, a bacterial infection is not responsible for the occurrence of purulent nasal discharge which may be a direct consequence of the viral infection.
本研究的目的是检查在普通感冒期间鼻腔和鼻咽部的细菌数量是否会发生变化。从29名自然感染感冒的成年患者的鼻腔以及26名成年患者的鼻咽部采集了用于细菌培养的样本。在出现首次鼻部症状后的第2天、第4天、第8天、第16天、第32天和第64天采集细菌学样本。结果显示，鼻腔和鼻咽部的病原菌很少。尽管大多数患者在第3 - 5天有肉眼可见的脓性分泌物，但在感冒期间阳性培养物数量没有增加的趋势。总之，该研究表明，在无并发症的普通感冒期间，脓性鼻涕的出现并非由细菌感染引起，而可能是病毒感染的直接后果。
