Weber S C, Chapman M W
Clin Orthop Relat Res. 1984 Dec(191):249-61.
Adhesives may offer a number of advantages over conventional metal osteosynthesis in the treatment of fractures: ease and speed of fixation are improved, they have the anatomy to anatomically coapt small fragments, and hardware removal is not necessary. A review of the literature was performed to evaluate experiments with collagen and other biologic adhesives, epoxy resins, polyurethane foam, cyanoacrylates, zinc polycarboxylate, polymethylmethacrylates, and fibrin adhesives pertaining to osteosynthesis. Cyanoacrylates, polymethylmethacrylates, and fibrin adhesives are currently being investigated. These agents are tested to evaluate their bone-bonding strength. Cyanoacrylates of biologically tolerated chain length did not develop useful bonding in cancellous bone; they bond well to cortical bone only with meticulous surface preparation. Fibrin adhesives developed only minimally useful bonding. Polymethylmethacrylate developed surgically useful bonding in osteosynthesis where conventional fixation is impossible.
在骨折治疗中，与传统金属接骨术相比，粘合剂可能具有诸多优势：固定操作更简便、速度更快，能够在解剖学上贴合小骨碎片，且无需取出内固定物。我们进行了文献综述，以评估胶原蛋白及其他生物粘合剂、环氧树脂、聚氨酯泡沫、氰基丙烯酸酯、聚羧酸锌、聚甲基丙烯酸甲酯和纤维蛋白粘合剂在接骨方面的实验。目前正在研究氰基丙烯酸酯、聚甲基丙烯酸甲酯和纤维蛋白粘合剂。对这些制剂进行测试以评估其骨结合强度。具有生物耐受性链长的氰基丙烯酸酯在松质骨中无法形成有效的结合；只有经过精心的表面处理，它们才能与皮质骨良好结合。纤维蛋白粘合剂仅形成了极小的有效结合。在无法进行传统固定的接骨术中，聚甲基丙烯酸甲酯形成了具有手术应用价值的结合。
