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与H-2相关的基因,其可改变C57BL/10小鼠对鼠麻风杆菌皮下感染的抵抗力。

H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.

作者信息

Curtis J, Akuffo-Adu H, Turk J L

出版信息

Infect Immun. 1984 Dec;46(3):635-8. doi: 10.1128/iai.46.3.635-638.1984.

Abstract

Strains of C57BL/10 mice with recombinants within the H-2 complex were used to map the genes which control the mononuclear cell response at the infection site and modify resistance to subcutaneous infection with Mycobacterium lepraemurium. Strains with b in the K-E beta regions of the H-2 complex mounted a more rapid cellular response in the infected footpad and were more resistant than mice with d or k in the K-E beta regions. Significant differences between strains with k in the K-E beta regions appeared to be controlled by a gene in the D region.

摘要

利用H-2复合体内带有重组体的C57BL/10小鼠品系来定位那些控制感染部位单核细胞反应并改变对鼠麻风杆菌皮下感染抵抗力的基因。H-2复合体K-Eβ区域带有b的品系在受感染的足垫中引发更快的细胞反应,并且比K-Eβ区域带有d或k的小鼠更具抵抗力。K-Eβ区域带有k的品系之间的显著差异似乎由D区域的一个基因控制。

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