Malkasian G D
Cancer. 1978 Mar;41(3):996-1001. doi: 10.1002/1097-0142(197803)41:3<996::aid-cncr2820410330>3.0.co;2-a.
Of 523 patients with endometrial carcinoma, 324 were FIGO stage Ia, 85 stage Ib, 24 stage II, 44 stage III, and 46 stage IV. High-grade lesions were present in 7.1% with stage Ia, 18.8% with stage Ib, 37.5% with stage II, 29.6% with stage III, and 55.3% with stage IV. There was no significant difference from expected survival at 5, 10, and 15 years for patients with IaG1 or IbG1 disease. Patients with IaG2 and IbG2 disease showed similar survival, as did patients with IaG3 and IbG3 disease. Thus, uterine size seemed to make no difference in patient survival at comparable grades of disease. Deaths due to cancer at 5 years increased from 63% for stage Ia disease to 100% for stage IV disease. By absolute measurement of penetration, with increasing stage of disease there was greater penetration whether the disease was low or high in grade. Also, as the grade increased within a given stage, so did penetration of the myometrium.
在523例子宫内膜癌患者中，国际妇产科联盟（FIGO）分期为Ia期的有324例，Ib期85例，II期24例，III期44例，IV期46例。Ia期高级别病变的比例为7.1%，Ib期为18.8%，II期为37.5%，III期为29.6%，IV期为55.3%。IaG1或IbG1疾病患者在5年、10年和15年的预期生存率与实际生存率无显著差异。IaG2和IbG2疾病患者的生存率相似，IaG3和IbG3疾病患者的生存率也相似。因此，在疾病分级相当的情况下，子宫大小似乎对患者生存率没有影响。5年时因癌症死亡的比例从Ia期疾病的63%上升到IV期疾病的100%。通过绝对测量浸润深度，无论疾病分级是低还是高，随着疾病分期增加，浸润深度也更大。而且，在给定分期内，随着分级增加，子宫肌层的浸润深度也增加。
