Malkasian G D, McDonald T W, Pratt J H
Mayo Clin Proc. 1977 Mar;52(3):175-80.
Five hundred and twenty-three patients with endometrial carcinoma treated at the Mayo Clinic from 1952 through 1962 have been followed up for a minimum of 10 years. These patients have been assigned International Federation of Gynecology and Obstetrics classifications retrospectively; 324 were stage IA and 85 were stage IB. Only 24 patients were stage II and 90 were stages III and IV, combined. Most patients were symptomatic, and a significantly greater number of stage IV patients had symptoms for a longer duration. The average age was 59 years; most patients were postmenopausal and there was a high degree of nulliparity. Seventeen and one-half percent of all patients in this series had a second carcinoma at some time, with breast and colon being the most common second primaries. Treatment was basically total hysterectomy and bilateral salpingooophorectomy with postoperative radiation added on an individualized basis. Seventy-four percent of the 523 patients survived 5 years and 64% survived 10 years. This varied from a 90% 5-year survival in 249 patients with stage IA or IB, G1, to a 13% 5-year survival in 46 patients with stage IV lesions.
1952年至1962年期间在梅奥诊所接受治疗的523例子宫内膜癌患者已得到至少10年的随访。这些患者已被回顾性地指定为国际妇产科联合会的分期；324例为IA期，85例为IB期。仅24例患者为II期，90例为III期和IV期（合并）。大多数患者有症状，且IV期患者出现症状的时间明显更长。平均年龄为59岁；大多数患者已绝经，且未生育比例很高。本系列所有患者中有17.5%在某个时候发生了第二种癌症，其中乳腺癌和结肠癌是最常见的第二原发性肿瘤。治疗基本上是全子宫切除术和双侧输卵管卵巢切除术，并根据个体情况术后加用放疗。523例患者中有74%存活了5年，64%存活了10年。这一比例从249例IA期或IB期、G1级患者的90% 5年生存率到46例IV期病变患者的13% 5年生存率不等。
