Gray P W, Aggarwal B B, Benton C V, Bringman T S, Henzel W J, Jarrett J A, Leung D W, Moffat B, Ng P, Svedersky L P
Nature. 1984;312(5996):721-4. doi: 10.1038/312721a0.
A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli. Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo.
编码人淋巴毒素的化学合成基因和天然互补DNA被分离出来，并进行工程改造以便在大肠杆菌中表达。纯化的重组淋巴毒素在体外对小鼠和人类肿瘤细胞系显示出细胞毒性活性，并在体内导致某些小鼠肉瘤坏死。
