大肠杆菌红霉素抗性突变体核糖体的特性
Properties of ribosomes from erythromycin resistant mutants of Escherichia coli.
作者信息
Pardo D, Rosset R
出版信息
Mol Gen Genet. 1977 Nov 18;156(3):267-71. doi: 10.1007/BF00267181.
PMID:340907
Abstract
We have studied the in vitro properties of ribosomes from several mutants resistant to erythromycin. Mutations in three different genes may confer resistance to erythromycin. Two of them are structural genes for proteins L4 and L22 of the large subunit. The third mutation (in eryC gene) seems to affect mainly the small subunit. The mechanism of action of the antibiotic may involve both subunits.
摘要
我们研究了几种对红霉素耐药的突变体核糖体的体外特性。三个不同基因中的突变可能会导致对红霉素产生耐药性。其中两个是大亚基中蛋白质L4和L22的结构基因。第三个突变（eryC基因中的突变）似乎主要影响小亚基。抗生素的作用机制可能涉及两个亚基。
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