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曲安奈德诱导未孕小鼠乳腺激活。

Triamcinolone-induced mammary activation in virgin mice.

作者信息

Lindenbaum E, Silberman M

出版信息

Eur J Pharmacol. 1978 Mar 1;48(1):133-6. doi: 10.1016/0014-2999(78)90051-1.

Abstract

Intact ICR mice receiving Triamcinolone showed extensive proliferation within the mammary gland. Galactophores and ducts were enlarged. In contrast with the non-treated animals, those treated with Triamcinolone had an evident lobuloalveolar system. Triamcinolone failed to activate the glands of oophorectomized animals. It is thus evident that systemic administration of Triamcinolone to young virgin mice causes mammary stimulation and that this effect only occurs in the presence of the ovary.

摘要

接受曲安奈德的完整ICR小鼠乳腺内出现广泛增殖。乳腺导管和腺管增大。与未治疗的动物相比,接受曲安奈德治疗的动物有明显的小叶腺泡系统。曲安奈德未能激活去卵巢动物的腺体。因此很明显,对年轻处女小鼠全身给予曲安奈德会引起乳腺刺激,且这种作用仅在有卵巢存在时才会发生。

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