Buffaloe G W, Erickson R R, Dau P C
J Clin Apher. 1983;1(2):86-94. doi: 10.1002/jca.2920010205.
A new parallel plate membrane plasma exchange system (Centry TPE System) has been developed and clinically evaluated. A series of 27 consecutive plasma exchanges were performed on 14 patients with autoimmune diseases. Blood access was obtained by routine means identical to centrifugal procedures. The blood flow rate was 94 +/- 20 ml/min and plasma filtration rate was 37 +/- 9 ml/min, with an average patient hematocrit of 36%. The sieving coefficients for a wide range of plasma solutes including immunoglobulins, immune complexes, and lipids, clustered about 1.00, indicating nonselective plasma filtration. The average reduction in patient plasma solutes of 60 to 70% was in close agreement with the predicted value for unhindered plasma filtration. There was no appreciable loss of blood cells, as compared to a study with a centrifugal system showing a 56% reduction in circulating platelets. Complement activation measured by C'3 conversion was undetectable in patient samples and either undetectable or minimal in plasma filtrate samples. The system was convenient to operate and problems were rare. No untoward patient effects attributable to the membrane system were observed. These results show that the parallel plate membrane plasma exchange system described in this report is capable of delivering safe, efficient plasma exchange.
一种新型平行板膜血浆置换系统（Centry TPE系统）已被研发并进行了临床评估。对14例自身免疫性疾病患者连续进行了27次血浆置换。通过与离心程序相同的常规方法建立血液通路。血流速度为94±20毫升/分钟，血浆滤过率为37±9毫升/分钟，患者平均血细胞比容为36%。包括免疫球蛋白、免疫复合物和脂质在内的多种血浆溶质的筛分系数集中在1.00左右，表明血浆滤过无选择性。患者血浆溶质平均减少60%至70%，与无阻碍血浆滤过的预测值密切相符。与一项离心系统研究相比，血细胞没有明显损失，该研究显示循环血小板减少了56%。通过C'3转化测量的补体激活在患者样本中检测不到，在血浆滤液样本中要么检测不到，要么非常轻微。该系统操作方便，问题很少。未观察到因膜系统导致的不良患者反应。这些结果表明，本报告中描述的平行板膜血浆置换系统能够提供安全、高效的血浆置换。
