Coffe C, Couteret Y, Pujol J P, Kieffer Y, Lenys R, Panouse J, Peters A
Int J Artif Organs. 1985 Jul;8 Suppl 2:43-8.
Two new filtration systems (Fenwal CPS 10TM - PS 400 and Organon Teknika Curesis - M82) were evaluated and compared with two centrifugal cell separators (IBM 2997 and Haemonetics V50). 11 patients with auto immune diseases and dermatological diseases underwent 230 consecutive plasma exchanges. For the filtration systems, the average whole blood rate was 50 ml/min and the plasma separation rate was about 21 ml/min for a transmembrane pressure about 70 mmHg. The pre/post percent reduction and sieving coefficient were calculated for some plasma and blood components. A variety of laboratory studies was monitored to assess the efficacy of plasma separators, their biocompatibility and some yields. These results show that the 2 filters appear safe and efficacious but their modules are too simple and do not offer a great security (no transmembrane pressure control or no extracorporeal fluid balance). For a blood banker, IBM 2997 seems more interesting if we take in account its characteristics during plasma exchanges and the possibility which is offered to carry out cytapheresis procedures. But for a thrombopenic patient the filtration systems keep their advantages.
对两种新型过滤系统（芬瓦尔德CPS 10TM - PS 400和奥加农·泰尼克Curesis - M82）进行了评估，并与两种离心式细胞分离器（IBM 2997和血液技术公司V50）进行了比较。11例患有自身免疫性疾病和皮肤病的患者连续进行了230次血浆置换。对于过滤系统，平均全血速率为50毫升/分钟，血浆分离速率约为21毫升/分钟，跨膜压约为70毫米汞柱。计算了一些血浆和血液成分的前后减少百分比和筛分系数。监测了各种实验室研究，以评估血浆分离器的功效、生物相容性和一些产量。这些结果表明，这两种过滤器似乎安全有效，但它们的模块过于简单，安全性不高（没有跨膜压控制或体外液体平衡）。对于血液库工作人员来说，如果考虑到IBM 2997在血浆置换过程中的特性以及进行血细胞分离术的可能性，它似乎更具吸引力。但对于血小板减少的患者，过滤系统仍具有优势。
