[Prostaglandin E1 (misoprostol) and S-adenosylmethionine in the prevention of hemorrhagic gastritis induced by aspirin in the human. Endoscopic, histologic and histochemical study].

On 58 healthy subjects, it was evaluated in endoscopic and histopathologic form, the cytoprotective effect on the gastroduodenal mucosa, such of T.G.E 1 (misoprostol) as of SAMe, in the present of acute bleeding gastritis induced by 1300 mg aspirin in a single dose and during 2 hours. SAMe was given in progressive doses up to 500 mg, which were ingested simultaneously with aspirin, and so with Misoprostol in doses of 50 mg, showed an endoscopic score of 0 without microscopic lesion of the gastroduodenal mucosa, this was confirmed by the histopathology, where both drugs give a cytoprotection of the gastroduodenal mucosa by about 95% of total biopsies gastrointestinal mucosa. It is suggest that T.G.E.1 (misoprostol) and SAMe are choice drugs in the treatment of hemorrhagic gastritis.