Allotypes of properdin factor B(Bf) and lymphocytotoxic antibody production.

We have investigated the properdin factor B(Bf) polymorphism in relation to lymphocytotoxic antibody production. The Bf phenotypes of 1,113 individuals was determined; these consisted of 360 cytotoxic antibody-negative normal healthy controls, 293 HLA typing antisera, 330 sera from pregnant multiparous women, and 130 renal patients awaiting cadaveric transplantation. The allotype BfF was found to be strongly associated with cytotoxic antibody production in multiparous women.