环孢素——人类生物免疫反应调节剂测试的一个模型。
Cyclosporine--a model for the testing of bio-immunological reaction modifiers in man.
作者信息
Powles R L, Evans B, Pedrazzini A, Crofts M, Hill P, Westensee W
出版信息
Med Oncol Tumor Pharmacother. 1984;1(2):137-9. doi: 10.1007/BF02934986.
PMID:6400032
Abstract
Cyclosporine is a member of a new family of drugs which interfere and modify the biological regulation of the immune system without being cytotoxic and has now been tested extensively in man. Observation of its toxicity in a homogeneous group of 72 patients with acute myeloblastic leukaemia receiving bone marrow transplants serves to illustrate some of the new and unexpected problems that may be seen when BIRM agents start to be tested in the clinic.
摘要
环孢素是一类新型药物的成员，这类药物可干扰并改变免疫系统的生物调节，且无细胞毒性，目前已在人体中进行了广泛测试。对72例接受骨髓移植的急性髓细胞白血病患者这一同质群体进行环孢素毒性观察，有助于说明当开始在临床中测试生物反应调节剂时可能会出现的一些新的和意想不到的问题。
Zotero 插件