Feery B J, Hartman L J, Hampson A W, Proietto J
WHO Influenza Centre, Commonwealth Serum Laboratories, Parkville, Victoria, Australia.
Diabetes Care. 1983 Sep-Oct;6(5):475-8. doi: 10.2337/diacare.6.5.475.
The antibody responses to influenza vaccination of a group of adult diabetic patients were compared with responses in a healthy group of regular volunteer vaccinees. The initial and final geometric mean hemagglutination-inhibiting antibody titers were lower in the patient group, but the relative increase in titers was greater for each of the vaccine components. The percentage of fourfold rises in individual titers was greater in the diabetic group than in the control group. It was concluded that patients with diabetes mellitus responded normally to influenza vaccination. This was confirmed in an additional study. There was no significant difference in the antibody responses of patients treated with insulin or oral antidiabetic agents. There was no impairment of diabetic control as a result of influenza vaccination when this was evaluated by measuring the concentration of glycosylated hemoglobin, or by random blood glucose estimations. There was no significant change in the serum insulin level after immunization in patients on oral diabetic agents. It was concluded that influenza vaccination was safe and effective in adult diabetic patients.
将一组成年糖尿病患者对流感疫苗接种的抗体反应与一组健康的定期志愿接种疫苗者的反应进行了比较。患者组的初始和最终几何平均血凝抑制抗体滴度较低，但每种疫苗成分的滴度相对增幅更大。糖尿病组个体滴度四倍升高的百分比高于对照组。得出的结论是，糖尿病患者对流感疫苗接种反应正常。这在另一项研究中得到了证实。接受胰岛素或口服抗糖尿病药物治疗的患者的抗体反应没有显著差异。通过测量糖化血红蛋白浓度或随机血糖估计值评估时，流感疫苗接种并未导致糖尿病控制受损。口服抗糖尿病药物的患者免疫后血清胰岛素水平没有显著变化。得出的结论是，流感疫苗接种对成年糖尿病患者是安全有效的。
