Hill-Zobel R L, Scheffel U, McIntyre P A, Tsan M F
Blood. 1983 Jan;61(1):149-53.
We have studied the kinetics, biodistribution, and fate of autologous platelets labeled with 111In-oxine in rabbits. The initial recovery was 75% and mean survival time was 2.8 days when the data were analyzed by the multiple-hit gamma function model. Using a modified geometric mean for correction of attenuation, there was good correlation between the values obtained by in vivo quantification and those obtained by postmortem measurements of the radioactivity in the liver and the spleen (i.e., r = 0.854 and 0.899, respectively, n = 32). Using this method, it was shown that after infusion, the 111In-platelets rapidly accumulated in these two organs reaching 35% and 12% of the injected dose in the liver and spleen, respectively, by 1 day. Thereafter, there was little subsequent change. On the sixth day, when essentially all of the 111In-platelets had cleared from the circulation, a total of 82% of the injected dose was deposited in the three major reticuloendothelial organs: liver (40%), spleen (14%), and bone marrow (28%). Our results suggest that in addition to liver and spleen, bone marrow played an important role in sequestering platelets in rabbits.
我们研究了用111铟-奥克辛标记的自体血小板在兔体内的动力学、生物分布及转归。采用多重打击伽马函数模型分析数据时，初始回收率为75%，平均存活时间为2.8天。使用修正几何平均数校正衰减后，体内定量获得的值与肝脏和脾脏放射性的死后测量值之间存在良好相关性（即，r分别为0.854和0.899，n = 32）。使用该方法表明，输注后，111铟标记的血小板迅速在这两个器官中蓄积，到第1天时，在肝脏和脾脏中分别达到注射剂量的35%和12%。此后，几乎没有后续变化。在第6天，当基本上所有111铟标记的血小板已从循环中清除时，总共82%的注射剂量沉积在三个主要的网状内皮器官中：肝脏（40%）、脾脏（14%）和骨髓（28%）。我们的结果表明，除肝脏和脾脏外，骨髓在兔体内血小板的隔离中也发挥了重要作用。
