Toghill P J, Green S
Gut. 1983 Jan;24(1):49-52. doi: 10.1136/gut.24.1.49.
Platelet dynamics in chronic liver disease have been studied using 111Indium-8-hydroxyquinolone (111In-oxine) as a platelet label. In 20 patients, mainly with alcoholic cirrhosis, the platelet mean life span was reduced in 12 and the splenic platelet pool increased, often markedly so, in 15. However, the platelet count was not significantly related to mean bile span, the splenic platelet pool, or spleen size. Whereas splenic platelet pool size is related to spleen size in most of the haematological 'big-spleen' syndromes, this did not apply to those patients with chronic liver disease. Technically, 111In-oxine is a more appropriate platelet label than 51Cr in ill and thrombocytopenic patients with liver disease.
已使用铟 - 111标记的8 - 羟基喹啉（铟 - 111 - 奥克辛）作为血小板标记物来研究慢性肝病中的血小板动力学。在20例主要为酒精性肝硬化的患者中，12例患者的血小板平均寿命缩短，15例患者的脾脏血小板池增加，且常常显著增加。然而，血小板计数与平均寿命、脾脏血小板池或脾脏大小并无显著关联。在大多数血液学“大脾脏”综合征中，脾脏血小板池大小与脾脏大小相关，但这不适用于慢性肝病患者。从技术层面讲，对于患有肝病的患病且血小板减少的患者，铟 - 111 - 奥克辛是比铬 - 51更合适的血小板标记物。
