使用111铟氧喹啉标记研究慢性肝病中的血小板动力学。
Platelet dynamics in chronic liver disease using the 111Indium oxine label.
作者信息
Toghill P J, Green S
出版信息
Gut. 1983 Jan;24(1):49-52. doi: 10.1136/gut.24.1.49.
Abstract
Platelet dynamics in chronic liver disease have been studied using 111Indium-8-hydroxyquinolone (111In-oxine) as a platelet label. In 20 patients, mainly with alcoholic cirrhosis, the platelet mean life span was reduced in 12 and the splenic platelet pool increased, often markedly so, in 15. However, the platelet count was not significantly related to mean bile span, the splenic platelet pool, or spleen size. Whereas splenic platelet pool size is related to spleen size in most of the haematological 'big-spleen' syndromes, this did not apply to those patients with chronic liver disease. Technically, 111In-oxine is a more appropriate platelet label than 51Cr in ill and thrombocytopenic patients with liver disease.
摘要
已使用铟 - 111标记的8 - 羟基喹啉（铟 - 111 - 奥克辛）作为血小板标记物来研究慢性肝病中的血小板动力学。在20例主要为酒精性肝硬化的患者中，12例患者的血小板平均寿命缩短，15例患者的脾脏血小板池增加，且常常显著增加。然而，血小板计数与平均寿命、脾脏血小板池或脾脏大小并无显著关联。在大多数血液学“大脾脏”综合征中，脾脏血小板池大小与脾脏大小相关，但这不适用于慢性肝病患者。从技术层面讲，对于患有肝病的患病且血小板减少的患者，铟 - 111 - 奥克辛是比铬 - 51更合适的血小板标记物。
相似文献
1
Platelet dynamics in chronic liver disease using the 111Indium oxine label.使用111铟氧喹啉标记研究慢性肝病中的血小板动力学。
Gut. 1983 Jan;24(1):49-52. doi: 10.1136/gut.24.1.49.
2
Measurement of platelet life-span in normal subjects and patients with myeloproliferative disease with indium oxine labelled platelets.用氧铟标记血小板测定正常人和骨髓增殖性疾病患者的血小板寿命。
Br J Haematol. 1984 Dec;58(4):679-87. doi: 10.1111/j.1365-2141.1984.tb06115.x.
3
111In-oxine platelet survivals in thrombocytopenic infants.111铟 - 奥克辛在血小板减少症婴儿中的血小板存活情况。
Blood. 1987 Sep;70(3):652-6.
4
Kinetics and distribution in vivo of 111In-labelled autologous platelets in idiopathic thrombocytopenic purpura.111铟标记的自体血小板在特发性血小板减少性紫癜中的体内动力学及分布
Scand J Haematol. 1985 Jan;34(1):47-56. doi: 10.1111/j.1600-0609.1985.tb00743.x.
5
Radionuclide distribution following injection of 111Indium-labelled platelets.注射111铟标记血小板后的放射性核素分布。
Br J Haematol. 1980 Dec;46(4):595-602. doi: 10.1111/j.1365-2141.1980.tb06017.x.
6
Indium-III: a new radionuclide label for studying human platelet kinetics.铟-III：一种用于研究人体血小板动力学的新型放射性核素标记物。
Br J Haematol. 1979 Aug;42(4):613-22. doi: 10.1111/j.1365-2141.1979.tb01174.x.
7
8
Use of indium-111/oxine to label human platelets.使用铟-111/8-羟基喹啉标记人血小板。
Lancet. 1978 Aug 26;2(8087):483. doi: 10.1016/s0140-6736(78)91499-x.
9
Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods.正常人体铟-111血小板动力学：托酚酮法与8-羟基喹啉法的比较
J Nucl Med. 1986 Nov;27(11):1669-74.
10
Kinetics and sites of destruction of 111Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study.特发性血小板减少性紫癜中¹¹¹铟-氧喹啉标记血小板的破坏动力学及部位：一项定量研究。
Am J Hematol. 1982 Apr;12(2):167-77. doi: 10.1002/ajh.2830120209.
引用本文的文献
1
The Effect of Transjugular Intrahepatic Portosystemic Shunt on Platelet Counts in Patients With Liver Cirrhosis.经颈静脉肝内门体分流术对肝硬化患者血小板计数的影响
Gastroenterol Hepatol (N Y). 2017 May;13(5):286-291.
2
Platelet IgG antibodies are significantly increased in chronic liver disease.慢性肝病患者的血小板IgG抗体显著增加。
Ann Gastroenterol. 2011;24(1):47-52.
3
Mechanisms of thrombocytopenia induced by interferon therapy for chronic hepatitis B.慢性乙型肝炎干扰素治疗所致血小板减少症的机制
J Gastroenterol. 1997 Apr;32(2):206-10. doi: 10.1007/BF02936369.
4
Mechanism of thrombocytopenia in liver cirrhosis: kinetics of indium-111 tropolone labelled platelets.肝硬化中血小板减少的机制：铟-111 托酚酮标记血小板的动力学
Eur J Nucl Med. 1993 Feb;20(2):123-9. doi: 10.1007/BF00168872.
5
Course of thrombocytopenia of chronic liver disease after transjugular intrahepatic portosystemic shunts (TIPS). A retrospective analysis.经颈静脉肝内门体分流术（TIPS）后慢性肝病血小板减少症的病程。一项回顾性分析。
Dig Dis Sci. 1995 Jul;40(7):1575-80. doi: 10.1007/BF02285211.
6
Haemostatic problems in liver disease.肝病中的止血问题。
Gut. 1986 Mar;27(3):339-49. doi: 10.1136/gut.27.3.339.
本文引用的文献
1
Indium (111In)-labelled human platelets: optimal method.铟（¹¹¹In）标记的人血小板：最佳方法。
Clin Sci (Lond). 1980 Mar;58(3):243-8. doi: 10.1042/cs0580243.
2
Kinetics, distribution and sites of destruction of 111indium-labelled human platelets.铟-111标记的人血小板的动力学、分布及破坏部位
Br J Haematol. 1980 Feb;44(2):269-80. doi: 10.1111/j.1365-2141.1980.tb01209.x.
3
Radionuclide distribution following injection of 111Indium-labelled platelets.注射111铟标记血小板后的放射性核素分布。
Br J Haematol. 1980 Dec;46(4):595-602. doi: 10.1111/j.1365-2141.1980.tb06017.x.
4
The effect of chromium on platelet function in vitro.铬对体外血小板功能的影响。
Blood. 1970 May;35(5):659-68.
5
The exchangeable splenic platelet pool studied with epinephrine infusion in idiopathic thrombocytopenic purpura and in patients with splenomegaly.通过肾上腺素输注研究特发性血小板减少性紫癜和脾肿大患者的可交换脾血小板池。
Br J Haematol. 1973 Aug;25(2):239-48. doi: 10.1111/j.1365-2141.1973.tb01735.x.
6
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy.血小板减少症中的（51铬）血小板动力学。血小板脾扣押与脾切除术反应之间的相关性。
Ann Intern Med. 1974 Jun;80(6):702-7. doi: 10.7326/0003-4819-80-6-702.
7
A six-channel automated platelet aggregometer.一台六通道自动血小板聚集仪。
Thromb Diath Haemorrh. 1975 Dec 15;34(3):821-4.
8
Platelet dynamics in chronic liver disease with special reference to the role of the spleen.慢性肝病中的血小板动力学，特别提及脾脏的作用。
J Clin Pathol. 1977 Apr;30(4):367-71. doi: 10.1136/jcp.30.4.367.
9
Indium-LLL labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions.铟-111标记血小板：体外及体内功能的制备与评估研究
Thromb Res. 1976 Oct;9(4):345-57. doi: 10.1016/0049-3848(76)90135-3.
10
Assessment of thrombocytopenic patients for splenectomy.对血小板减少症患者进行脾切除术的评估。
J Clin Pathol. 1979 Dec;32(12):1248-52. doi: 10.1136/jcp.32.12.1248.
Zotero 插件