Bautista A P, Buckler P W, Towler H M, Dawson A A, Bennett B
Br J Haematol. 1984 Dec;58(4):679-87. doi: 10.1111/j.1365-2141.1984.tb06115.x.
The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlusion and this abnormality persisted after reduction of the platelet count to normal by busulphan therapy. Patients with similarly elevate platelet counts due to chronic granulocytic leukaemia or after splenectomy had platelet life-span values in the normal range. Plasma beta-TG levels could not be used to predict platelet life-span in these groups of patients. Measurement of platelet life-span using 111Indium labelled platelets is a useful technique in the examination of platelet function in occlusive vascular disease.
已对使用氧肟酸铟-111作为血小板标记物进行血小板寿命研究进行了考察。正常受试者的血小板寿命在8×10至10×36天之间。原发性血小板增多症患者无论是否出现血管闭塞，其血小板寿命均明显缩短，且在通过白消安治疗使血小板计数降至正常后，这种异常仍持续存在。因慢性粒细胞白血病或脾切除术后血小板计数同样升高的患者，其血小板寿命值在正常范围内。血浆β-血小板球蛋白水平不能用于预测这些患者组的血小板寿命。使用铟-111标记血小板测量血小板寿命是检查闭塞性血管疾病中血小板功能的一项有用技术。
