Greenway B, Iqbal M J, Johnson P J, Williams R
Br Med J (Clin Res Ed). 1983 Jan 8;286(6359):93-5. doi: 10.1136/bmj.286.6359.93.
The detection of high activities of two sex-steroid biosynthetic enzymes-aromatase and 5-alpha-reductase-in pancreatic carcinoma tissue suggested the possibility that these enzymes may influence the circulating concentrations of sex-steroid hormones. Mean serum testosterone concentrations in 22 men and women with exocrine carcinoma of the pancreas were significantly lower than those in 20 healthy controls and 27 patients with other known malignancies, who were of similar age and sex composition. Low serum testosterone concentrations may be due to uptake by and metabolism within the tumour; alternatively, patients with low androgen concentrations may be at greater risk of developing pancreatic carcinoma.
在胰腺癌组织中检测到两种性甾体生物合成酶——芳香化酶和5-α-还原酶的高活性，提示这些酶可能影响性甾体激素的循环浓度。22例胰腺外分泌癌男性和女性患者的血清睾酮平均浓度显著低于20例健康对照者以及27例年龄和性别构成相似的其他已知恶性肿瘤患者。血清睾酮浓度低可能是由于肿瘤摄取和代谢所致；或者，雄激素浓度低的患者患胰腺癌的风险可能更高。
