Lockitch G, Godolphin W, Pendray M R, Riddell D, Quigley G
J Pediatr. 1983 Feb;102(2):304-8. doi: 10.1016/s0022-3476(83)80548-4.
One hundred twenty-seven newborn infants requiring parenteral nutrition were randomly assigned to receive differing amounts of zinc (40 to 400 micrograms/kg/day) and copper (20 or 40 micrograms/kg/day) supplementation within five birth weight groups (600 to 2,500 gm). The serum zinc concentration remained relatively constant in the group receiving the most zinc supplementation after two weeks of therapy, but declined sharply in the groups receiving less supplementation. No effect of increased copper intake was noted on ceruloplasmin values, but a difference in serum copper concentrations was noted at two weeks. No correlation was noted between serum zinc and copper values or among those for serum zinc, retinol-binding protein, and prealbumin. Reference ranges were defined for serum zinc, copper, retinol-binding protein, prealbumin, and ceruloplasmin in the preterm infant.
127名需要肠外营养的新生儿被随机分配到五个出生体重组（600至2500克）中，接受不同剂量的锌（40至400微克/千克/天）和铜（20或40微克/千克/天）补充。治疗两周后，接受最多锌补充的组中血清锌浓度保持相对稳定，但接受较少补充的组中血清锌浓度急剧下降。未观察到增加铜摄入量对铜蓝蛋白值有影响，但在两周时观察到血清铜浓度存在差异。血清锌和铜值之间或血清锌、视黄醇结合蛋白和前白蛋白值之间未观察到相关性。确定了早产儿血清锌、铜、视黄醇结合蛋白、前白蛋白和铜蓝蛋白的参考范围。
