Lowry S F, Smith J C, Brennan M F
Am J Clin Nutr. 1981 Sep;34(9):1853-60. doi: 10.1093/ajcn/34.9.1853.
A prospective study of zinc and copper replacement concurrently with total parenteral nutrition was undertaken during 29 courses of total parenteral nutrition in 20 tumor-bearing patients. Urinary excretion of zinc and copper was prospectively studied in eight of these subjects. While progressive declines in zinc and copper blood levels occurred in four unsupplemented control patients, maintenance of plasma trace metal concentrations within normal limits was accomplished by daily intravenous zinc and copper. A daily intravenous intake of 70 to 80 micrograms/kg of zinc and 60 to 65 micrograms/kg of copper were generally associated with normal blood levels and positive urinary balance of these trace elements. This study outlines a safe and effective zinc and copper replacement regimen in patients undergoing total parenteral nutrition.
对20例肿瘤患者进行了29个疗程的全胃肠外营养，并同时进行锌和铜补充的前瞻性研究。对其中8名受试者的锌和铜尿排泄情况进行了前瞻性研究。4例未补充的对照患者的锌和铜血水平逐渐下降，而通过每日静脉补充锌和铜，可将血浆微量元素浓度维持在正常范围内。每日静脉摄入70至80微克/千克的锌和60至65微克/千克的铜，通常可使这些微量元素的血水平正常且尿平衡呈阳性。本研究概述了全胃肠外营养患者安全有效的锌和铜补充方案。
