Stoner H B, Little R A, Frayn K N, Elebute A E, Tresadern J, Gross E
Br J Surg. 1983 Jan;70(1):32-5. doi: 10.1002/bjs.1800700113.
Oxidative metabolism has been studied by indirect calorimetry in 27 patients with sepsis and in 7 non-septic patients while they were all receiving total parenteral nutrition. Glucose oxidation was reduced in the septic patients and fat oxidation continued despite the infusion of an excess of glucose. The extent of these changes depended on the severity of the septic state as measured by the scoring system described in the preceding paper. The mechanism of these changes is not known. They were not related to an elevation of the plasma nonesterified fatty acid concentration. Alterations must have occurred in the way fat was taken up and metabolized by the cells. Here insulin resistance and the highly significant positive relationship found between the plasma cortisol concentration and the sepsis score might be important.
在27例脓毒症患者和7例非脓毒症患者接受全胃肠外营养期间，通过间接测热法对氧化代谢进行了研究。脓毒症患者的葡萄糖氧化减少，尽管输注了过量葡萄糖，脂肪氧化仍在继续。这些变化的程度取决于前一篇论文中描述的评分系统所衡量的脓毒症状态的严重程度。这些变化的机制尚不清楚。它们与血浆非酯化脂肪酸浓度的升高无关。细胞摄取和代谢脂肪的方式肯定发生了改变。在此，胰岛素抵抗以及血浆皮质醇浓度与脓毒症评分之间发现的高度显著正相关可能很重要。
