Dahn M S, Kirkpatrick J R, Blasier R
JPEN J Parenter Enteral Nutr. 1984 Mar-Apr;8(2):169-73. doi: 10.1177/0148607184008002169.
The responses to an exogenous lipid challenge of nonhypermetabolic surgical patients requiring parenteral nutrition and seriously ill septic patients were compared. All patients received a 500-ml intravenous infusion of a 10% lipid emulsion over a 4-hr period. An early elevation of glycerol and triglyceride was noted during the infusion suggesting chylomicron fractionation. Peak triglyceride levels were higher in the septic group but the rate of lipid clearance appeared essentially identical in both septic and nonseptic patients. Lipoprotein lipase levels remained constant and were equal for both groups. Significant late ketone body production was statistically identical in both groups despite depressed albumin levels in the septic group suggesting adequate hepatic ketogenic capacity in septic as well as nonseptic patients.
对需要肠外营养的非高代谢手术患者和重症脓毒症患者对外源性脂质挑战的反应进行了比较。所有患者在4小时内接受了500毫升10%脂质乳剂的静脉输注。输注期间甘油和甘油三酯早期升高，提示乳糜微粒分级。脓毒症组的甘油三酯峰值水平较高，但脓毒症患者和非脓毒症患者的脂质清除率基本相同。脂蛋白脂肪酶水平保持恒定，两组相等。尽管脓毒症组白蛋白水平降低，但两组晚期酮体的显著产生在统计学上相同，提示脓毒症患者和非脓毒症患者均有足够的肝脏生酮能力。
