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马来环蛇(Bungarus candidus,林奈)所致严重神经毒性中毒:对抗蛇毒血清和抗胆碱酯酶的反应

Severe neurotoxic envenoming by the Malayan krait Bungarus candidus (Linnaeus): response to antivenom and anticholinesterase.

作者信息

Warrell D A, Looareesuwan S, White N J, Theakston R D, Warrell M J, Kosakarn W, Reid H A

出版信息

Br Med J (Clin Res Ed). 1983 Feb 26;286(6366):678-80. doi: 10.1136/bmj.286.6366.678.

Abstract

Five patients were bitten by the Malayan krait Bungarus candidus (Linnaeus) in eastern Thailand or north western Malaya. Two patients were not envenomed but the other three developed generalised paralysis which progressed to respiratory paralysis in two cases, one of which ended fatally. One patient showed parasympathetic abnormalities. Anticholinesterase produced a dramatic improvement in one patient. Another patient probably benefited from paraspecific antivenom. The efficacy of antivenoms and adjuvants such as anticholinesterases in patients with neurotoxic envenoming requires further study.

摘要

5名患者在泰国东部或马来西亚西北部被马来环蛇(Bungarus candidus,林奈)咬伤。2名患者未出现中毒症状,但其他3名患者出现全身麻痹,其中2例进展为呼吸麻痹,1例死亡。1名患者出现副交感神经异常。抗胆碱酯酶药物使1名患者病情显著改善。另1名患者可能受益于异种特异性抗蛇毒血清。抗蛇毒血清和抗胆碱酯酶等佐剂在神经毒性中毒患者中的疗效需要进一步研究。

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