Minton J P, Abou-Issa H, Foecking M K, Sriram M G
Cancer. 1983 Apr 1;51(7):1249-53. doi: 10.1002/1097-0142(19830401)51:7<1249::aid-cncr2820510713>3.0.co;2-q.
The following study was carried out to determine the possibility of caffeine being a promoter of breast cancer development in animals consuming vegetable fat. A controlled study, comparing the time of mammary tumor development and the number of tumors was carried out in Sprague-Dawley rats which had been given 20 mg of DMBA at seven weeks of age. This study evaluated the tumor promotional effects of caffeine alone, caffeine and unsaturated fat in combination, unsaturated fat alone, and a standard rat chow diet. The results show that the rats which consumed caffeine and unsaturated fat had the earliest development of tumor and the most multiple tumor occurrence. Average time to tumor development was 95 days. The fat or standard chow rats had an average time to tumor development of 134 and 140 days, respectively. The caffeine-alone rats had a mean time to tumor development of 188 days. The combination of an unsaturated fat diet and caffeine significantly shortened the time to tumor development when compared with the other three groups.
进行以下研究以确定咖啡因是否有可能促进食用植物脂肪的动物发生乳腺癌。在7周龄时给予20毫克二甲基苯蒽（DMBA）的斯普拉格-道利大鼠中开展了一项对照研究，比较乳腺肿瘤发生的时间和肿瘤数量。该研究评估了单独使用咖啡因、咖啡因与不饱和脂肪联合使用、单独使用不饱和脂肪以及标准大鼠饲料饮食对肿瘤的促进作用。结果显示，摄入咖啡因和不饱和脂肪的大鼠肿瘤发生最早且肿瘤多发性最高。肿瘤发生的平均时间为95天。食用脂肪或标准饲料的大鼠肿瘤发生的平均时间分别为134天和140天。单独使用咖啡因的大鼠肿瘤发生的平均时间为188天。与其他三组相比，不饱和脂肪饮食和咖啡因的组合显著缩短了肿瘤发生的时间。
