Bobkov Iu G, Morozov I S, Glozman O M, Nerobkova L N, Zhmurenko L A
Biull Eksp Biol Med. 1983 Apr;95(4):50-3.
The central neurotropic effects of 4-phenylpyracetam, a new phenyl analog of pyracetam, were studied and compared with the effects of pyracetam, morpholene and 4-phenylpyrrolidone. 4-Phenylpyracetam was found to activate the operant behavior more powerfully, to remove psychodepressant effects of diazepam, to inhibit post-rotational nystagmus, and to prevent the development of retrograde amnesia. Unlike pyracetam, 4-phenylpyracetam exhibits a specific anticonvulsant action. When given in high doses, the compound under study produces psychodepressant effects.
研究了新型吡拉西坦苯基类似物4-苯基吡拉西坦的中枢神经趋向性作用,并与吡拉西坦、吗啉和4-苯基吡咯烷酮的作用进行了比较。发现4-苯基吡拉西坦能更有力地激活操作性行为,消除地西泮的精神抑制作用,抑制旋转后眼球震颤,并预防逆行性遗忘的发生。与吡拉西坦不同,4-苯基吡拉西坦具有特异性抗惊厥作用。高剂量给药时,所研究的化合物会产生精神抑制作用。