Skegg K, Skegg D C, Richards S M
Br Med J (Clin Res Ed). 1983 Mar 12;286(6368):841-3. doi: 10.1136/bmj.286.6368.841.
The drugs most commonly used in self poisoning are the psychotropics, but the proportion of patients given these drugs who take overdoses is unknown. In a prospective study of 43117 people in Oxfordshire, prescriptions issued by general practitioners were linked with records of hospital admissions and deaths. During two years there were 79 episodes of deliberate self poisoning leading to hospital admission or death. The number of patients who took overdoses of psychotropic drugs was small in relation to the total number prescribed such drugs. Of 5600 people aged 10 or older who received psychotropic drugs during one year, 17 (3.0 per 1000) poisoned themselves with these drugs within 12 months. The rate of self poisoning with psychotropic drugs declined significantly with increasing age (p less than 0.001). Almost three quarters of the patients who took overdoses of prescribed psychotropics received further psychotropic drugs during the three months after their admission to hospital.
自我中毒最常用的药物是精神药物,但服用这些药物过量的患者比例尚不清楚。在对牛津郡43117人的一项前瞻性研究中,全科医生开出的处方与医院入院和死亡记录相关联。在两年期间,有79起蓄意自我中毒事件导致住院或死亡。与所开精神药物的总数相比,服用精神药物过量的患者数量较少。在一年中接受精神药物治疗的5600名10岁及以上的人中,有17人(每1000人中有3.0人)在12个月内用这些药物自我中毒。精神药物自我中毒率随年龄增长而显著下降(p小于0.001)。几乎四分之三服用处方精神药物过量的患者在入院后的三个月内又接受了精神药物治疗。