Verstraete A G, Bogaert M G, Buylaert W A
Central Laboratory, University Hospital Gent, Belgium.
Eur J Clin Pharmacol. 1990;39(5):519-20. doi: 10.1007/BF00280947.
Since January 1 1988, certain older hypnotics have no longer been available over the counter in Belgium, but can still be dispensed on prescription. The influence of this measure on admission to our Emergency Department for acute poisoning with these hypnotics has been examined. From 1983 to 1987, a mean of 93 patients (range 87 to 99) per year were admitted as compared to 15 and 5 in 1988 and 1989, respectively. For older hypnotics that were on prescription before and after 1st January 1988, there was no decrease in 1988, and a reduction was observed in 1989. There was no change in the number of patients with benzodiazepine poisoning. The data indicate that moving these older hypnotics onto the prescription-only list resulted in a decrease in acute poisoning with them. The reduction observed in 1989 for the older hypnotics that were on prescription before as well as after 1988 may have been due to an influence of the measure on the prescribing habits of physicians.
自1988年1月1日起，某些较老的催眠药在比利时不再可在柜台购买，但仍可凭处方配药。已对该措施对因这些催眠药急性中毒而入住我们急诊科的影响进行了研究。1983年至1987年，每年平均有93名患者（范围为87至99名）入院，而1988年和1989年分别为15名和5名。对于1988年1月1日之前和之后凭处方使用的较老催眠药，1988年没有减少，1989年观察到有所减少。苯二氮䓬类中毒患者的数量没有变化。数据表明，将这些较老的催眠药列入仅凭处方购买的清单导致了因它们引起的急性中毒的减少。1989年观察到的1988年之前和之后凭处方使用的较老催眠药的减少可能是由于该措施对医生处方习惯的影响。
