低血清C4浓度：胰岛素依赖型糖尿病的遗传易感性？
Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?
作者信息
Vergani D, Johnston C, B-Abdullah N, Barnett A H
出版信息
Br Med J (Clin Res Ed). 1983 Mar 19;286(6369):926-8. doi: 10.1136/bmj.286.6369.926.
Abstract
Twenty two out of 86 insulin dependent diabetics had serum C4 concentrations below the normal range. None of 41 non-insulin dependent diabetics tested had low concentrations. Low C4 values were seen in insulin dependent diabetes irrespective of the duration of the disease and did not appear to correlate with complement activation. There was a close correlation in C4 values between identical cotwins, even when only one was diabetic. These results suggest that a low serum C4 concentration is an inherited phenomenon and may predispose towards the development of insulin dependent diabetes.
摘要
86名胰岛素依赖型糖尿病患者中有22人的血清C4浓度低于正常范围。41名接受检测的非胰岛素依赖型糖尿病患者中无人C4浓度低。胰岛素依赖型糖尿病患者不论病程长短均可见C4值低，且似乎与补体激活无关。同卵双胞胎即使只有一人患糖尿病，其C4值也密切相关。这些结果表明血清C4浓度低是一种遗传现象，可能易导致胰岛素依赖型糖尿病的发生。
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