肺活量测定值正常的成年哮喘患者的支气管反应性
Bronchial reactivity in asthmatic adults with normal spirometric values.
作者信息
Higenbottam T, Stokes T C, Jamieson S, Hill L
出版信息
Br Med J (Clin Res Ed). 1983 Mar 26;286(6370):1012-4. doi: 10.1136/bmj.286.6370.1012.
A comparison was made between airways obstruction produced by exercise. Hyperventilation of cold air, hyperventilation of room air, and inhalation of ultrasonically nebulised distilled water. Seven asthmatics with no airflow obstruction were studied together with seven normal controls. All four provocations produced comparable mean reductions in forced expired volume in one second in the asthmatic patients, but no reduction was obtained in the controls. Whereas exercise, hyperventilation of cold air, and hyperventilation of room air were associated with heat loss from airways, inhalation of nebulised distilled water was not. Inhalation of ultrasonically nebulised distilled water offers a simple additional diagnostic test for asthma. Changes in the osmolality of airway surface liquid may possibly be the common mechanism by which "fog" and hyperventilation produce bronchoconstruction.
对运动诱发的气道阻塞、冷空气过度通气、室内空气过度通气以及吸入超声雾化蒸馏水所产生的气道阻塞进行了比较。对7名无气流阻塞的哮喘患者和7名正常对照者进行了研究。所有这四种激发试验在哮喘患者中均导致一秒用力呼气量出现类似的平均降低，但在对照者中未出现降低。运动、冷空气过度通气和室内空气过度通气与气道热量散失有关，而吸入雾化蒸馏水则不然。吸入超声雾化蒸馏水为哮喘提供了一种简单的辅助诊断试验。气道表面液体渗透压的变化可能是“雾气”和过度通气产生支气管收缩的共同机制。
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