King M M, McCay P B
Cancer Res. 1983 May;43(5 Suppl):2485s-2490s.
The interaction of effects of various levels and types of dietary fat and antioxidants on 7,12-dimethylbenz(alpha)anthracene- and nitrosomethylurea-induced mammary gland carcinogenesis has been studied. Dramatic differences were noted with respect to dietary fat effects as has been reported previously by others as well as ourselves. A dependence upon dietary fat type and amount, as well as upon whether diets are undefined laboratory chows or semipurified diets, is examined with regard to the effectiveness of antioxidants as tumor-inhibitory agents. The possible role and function of "antioxidants" as a class of compounds in chemical as well as the more complex biological system are discussed. A brief summary of the effectiveness of specific antioxidants in various tumor models as well as sex differences is presented, with a concluding discussion of possible strategies for obtaining information on the mechanism by which various dietary substances with antioxidant properties may inhibit tumorigenesis.
已研究了不同水平和类型的膳食脂肪与抗氧化剂对7,12-二甲基苯并（α）蒽和亚硝基甲基脲诱导的乳腺肿瘤发生的相互作用。正如其他人以及我们自己之前所报道的，在膳食脂肪效应方面发现了显著差异。就抗氧化剂作为肿瘤抑制剂的有效性而言，研究了其对膳食脂肪类型和数量的依赖性，以及膳食是未定义的实验室饲料还是半纯化饲料的情况。讨论了“抗氧化剂”作为一类化合物在化学以及更复杂的生物系统中的可能作用和功能。简要总结了特定抗氧化剂在各种肿瘤模型中的有效性以及性别差异，并对获取具有抗氧化特性的各种膳食物质抑制肿瘤发生机制信息的可能策略进行了总结讨论。
