Puzich R, Girke W, Heidrich H, Rischke M
Dtsch Med Wochenschr. 1983 Mar 25;108(12):457-61. doi: 10.1055/s-2008-1069578.
Doppler ultrasound investigations were done in 20 patients with migraine during the symptom-free interval after oral administration of 2 mg and 6 mg ergotamine tartrate. The observed changes of end-diastolic flow velocity as a measure of peripheral total resistance permit simultaneous assessment of the vasoconstrictor effect of ergotamine in the perfusion area of the internal and external carotid arteries. A dosage of 2 mg led to an exclusive increase of resistance in the external carotid artery area without significant changes in the internal carotid area. A maximal therapeutic dosage of 6 mg ergotamine tartrate did not lead to a significant increase of the vasoconstrictor effect in the external carotid circulation. In addition, a barely registrable increase of resistance in the internal carotid area could now be observed.
对20名偏头痛患者在口服2毫克和6毫克酒石酸麦角胺后的无症状间歇期进行了多普勒超声检查。通过观察舒张末期血流速度的变化来衡量外周总阻力，从而能够同时评估麦角胺对内、外颈动脉灌注区域的血管收缩作用。2毫克的剂量导致颈外动脉区域阻力单独增加，而颈内动脉区域无明显变化。6毫克酒石酸麦角胺的最大治疗剂量并未导致颈外动脉循环中血管收缩作用显著增强。此外，此时可观察到颈内动脉区域阻力有轻微的、几乎难以察觉的增加。
