Barenbrock M, Spieker C, Witta J, Evers S, Hoeks A P, Rahn K H, Zidek W
Department of Medicine, University of Münster, Germany.
Hypertension. 1996 Jul;28(1):115-9. doi: 10.1161/01.hyp.28.1.115.
To investigate the effect of vascular smooth muscle contraction on mechanical vessel wall properties of proximal "elastic" arteries, we investigated the effect of the vasoconstrictor ergotamine on the distensibility of the common carotid artery in 10 migraine patients with ergotamine intake, in 10 control patients with migraine headache but no prior ergotamine intake, and in 10 healthy control subjects. The patients and control subjects were matched for age, blood pressure, and sex. In the ergotamine group, 2.2 +/- 1.4 mg ergotamine tartrate (0.25 to 6 mg) was taken within 12 hours before investigation. Differences in mean 24-hour blood pressure between the study groups were excluded by 24-hour blood pressure recording and differences in arterial wall thickness by high-resolution and differences in arterial wall thickness by high-resolution B-mode ultrasound. A multigate Doppler system was used for measurement of vessel wall movements by M-mode Doppler analysis. Blood pressure was determined by sphygmomanometry. The end-diastolic diameter of the common carotid artery was insignificantly reduced in the ergotamine group compared with the healthy control subjects and control patients (healthy control subjects, 6.6 +/- 0.4 mm; control patients, 6.7 +/- 0.5 mm; patients with ergotamine intake, 6.3 +/- 0.4 mm; P = NS). Arterial distensibility was significantly lower in the patients with ergotamine intake (17.4 +/- 4.0 10(-3)/kPa) than in the healthy control subjects (22.3 +/- 5.1 10(-3)/kPa) and control patients (22.8 +/- 3.6 10(-3)/kPa) (one-way ANOVA, P = .014). The results show that ergotamine reduces the distensibility of the common carotid artery. The data suggest that vascular smooth muscle contraction can modulate the buffering function of the arterial system independently of blood pressure changes.
为研究血管平滑肌收缩对近端“弹性”动脉血管壁力学特性的影响，我们调查了血管收缩剂麦角胺对10名服用过麦角胺的偏头痛患者、10名有偏头痛但未服用过麦角胺的对照患者以及10名健康对照者颈总动脉扩张性的影响。患者和对照者在年龄、血压和性别方面相匹配。在麦角胺组中，在调查前12小时内服用了2.2±1.4mg酒石酸麦角胺（0.25至6mg）。通过24小时血压记录排除研究组之间24小时平均血压的差异，通过高分辨率B型超声排除动脉壁厚度的差异。使用多门多普勒系统通过M型多普勒分析测量血管壁运动。通过血压计测定血压。与健康对照者和对照患者相比，麦角胺组颈总动脉舒张末期直径略有减小（健康对照者，6.6±0.4mm；对照患者，6.7±0.5mm；服用麦角胺的患者，6.3±0.4mm；P=无显著性差异）。服用麦角胺的患者的动脉扩张性（17.4±4.0×10⁻³/kPa）显著低于健康对照者（22.3±5.1×10⁻³/kPa）和对照患者（22.8±3.6×10⁻³/kPa）（单因素方差分析，P=0.014）。结果表明，麦角胺降低了颈总动脉的扩张性。数据表明，血管平滑肌收缩可独立于血压变化调节动脉系统的缓冲功能。
