特定蛋白质的重新获得赋予肺炎支原体毒力。
Reacquisition of specific proteins confers virulence in Mycoplasma pneumoniae.
作者信息
Krause D C, Leith D K, Baseman J B
出版信息
Infect Immun. 1983 Feb;39(2):830-6. doi: 10.1128/iai.39.2.830-836.1983.
Abstract
Hemadsorbing revertants were isolated from spontaneous hemadsorption-negative, avirulent mutants of Mycoplasma pneumoniae. The revertants simultaneously reacquired specific proteins absent in their homologous mutants, along with neuraminidase-sensitive adherence to the respiratory epithelium and virulence. Peptide mapping and immunological analysis indicated no precursor-product relationships among certain of these proteins.
摘要
从肺炎支原体自发的血细胞吸附阴性、无毒力突变体中分离出血细胞吸附回复突变体。这些回复突变体同时重新获得了其同源突变体中不存在的特定蛋白质，以及对神经氨酸酶敏感的对呼吸道上皮的黏附性和毒力。肽图谱分析和免疫学分析表明，这些蛋白质中某些蛋白质之间不存在前体-产物关系。
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