类风湿关节炎中的Gm和Km同种异型
Gm and Km allotypes in rheumatoid arthritis.
作者信息
Sanders P A, de Lange G G, Dyer P A, Grennan D M
出版信息
Ann Rheum Dis. 1985 Aug;44(8):529-32. doi: 10.1136/ard.44.8.529.
Abstract
Immunoglobulin heavy chain (Gm) and kappa light chain (Km) allotype and phenotype frequencies were compared in 173 patients with rheumatoid arthritis (RA) and in 798 controls. No significant differences were found between allotype or phenotype frequencies in overall RA and control groups. However, the Gm(zaxfngb) phenotype and G1m(x) allotype were increased in HLA-DR4 positive RA patients compared with DR4 negative patients and controls, suggesting that immunoglobulin heavy chain genes interact with HLA in the pathogenesis of RA. All four patients with pulmonary fibrosis were Km(1) positive suggesting a possible role for immunoglobulin kappa light chain genes in the pathogenesis of pulmonary fibrosis found in rheumatoid patients.
摘要
在173例类风湿关节炎（RA）患者和798例对照中比较了免疫球蛋白重链（Gm）和κ轻链（Km）的同种异型和表型频率。在总体RA组和对照组之间，未发现同种异型或表型频率有显著差异。然而，与DR4阴性患者及对照组相比，HLA - DR4阳性RA患者的Gm（zaxfngb）表型和G1m（x）同种异型有所增加，提示免疫球蛋白重链基因在RA发病机制中与HLA相互作用。所有4例肺纤维化患者均为Km（1）阳性，提示免疫球蛋白κ轻链基因在类风湿患者中发现的肺纤维化发病机制中可能起作用。
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