鼠伤寒沙门氏菌制备的微小细胞与丝裂霉素C联合对荷EL4瘤小鼠的协同抗肿瘤作用。

Synergistic anti-tumor effect of mini-cells prepared from Salmonella typhimurium with mitomycin C in EL4-bearing mice.

作者信息

Kurashige S, Kodama K, Yoshida T

出版信息

Cancer Immunol Immunother. 1983;14(3):202-4. doi: 10.1007/BF00205361.

DOI:10.1007/BF00205361

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11039161/

Abstract

A statistically significant increase in survival time was observed in EL4-bearing mice after a mini-cell inoculation. However, no case of survival for over 30 days was observed after an EL4 graft in mice treated with mini-cells alone. Fifty percent of the mice survived for 40 days after an EL4 transplantation when the mice were treated with both an IV injection of mini-cells and an SC injection of mitomycin C. The mini-cell injection restored the macrophage chemotaxis activity in EL4-bearing mice but did not restore the lymphocyte activities.

摘要

在接种微型细胞后，携带EL4的小鼠的存活时间有统计学意义的显著增加。然而，仅用微型细胞处理的小鼠在移植EL4后未观察到存活超过30天的情况。当小鼠接受静脉注射微型细胞和皮下注射丝裂霉素C治疗时，50%的小鼠在EL4移植后存活了40天。微型细胞注射恢复了携带EL4的小鼠的巨噬细胞趋化活性，但未恢复淋巴细胞活性。

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本文引用的文献

1

Immunopotentiating activity of whole cells and mini-cells of Salmonella typhimurium.鼠伤寒沙门氏菌全细胞和微小细胞的免疫增强活性。

Microbiol Immunol. 1981;25(5):467-77. doi: 10.1111/j.1348-0421.1981.tb00049.x.

2

Enhancing effects of mini-cells prepared from Salmonella typhimurium on anti-tumor immunity in sarcoma 180-bearing mice.鼠伤寒沙门氏菌制备的微小细胞对荷肉瘤180小鼠抗肿瘤免疫的增强作用

Cancer Immunol Immunother. 1982;14(1):1-3. doi: 10.1007/BF00199423.

3

Macrophage activities in sarcoma 180-bearing mice and EL4-bearing mice.荷肉瘤180小鼠和荷EL4小鼠中的巨噬细胞活性。

Gan. 1982 Feb;73(1):85-90.

4

Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation.用胎牛血清预处理塑料培养皿。一种分离巨噬细胞的简单方法。

J Immunol Methods. 1979;29(1):17-25. doi: 10.1016/0022-1759(79)90121-2.

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