Kurashige S, Kodama K, Yoshida T
Cancer Immunol Immunother. 1983;14(3):202-4. doi: 10.1007/BF00205361.
A statistically significant increase in survival time was observed in EL4-bearing mice after a mini-cell inoculation. However, no case of survival for over 30 days was observed after an EL4 graft in mice treated with mini-cells alone. Fifty percent of the mice survived for 40 days after an EL4 transplantation when the mice were treated with both an IV injection of mini-cells and an SC injection of mitomycin C. The mini-cell injection restored the macrophage chemotaxis activity in EL4-bearing mice but did not restore the lymphocyte activities.
在接种微型细胞后，携带EL4的小鼠的存活时间有统计学意义的显著增加。然而，仅用微型细胞处理的小鼠在移植EL4后未观察到存活超过30天的情况。当小鼠接受静脉注射微型细胞和皮下注射丝裂霉素C治疗时，50%的小鼠在EL4移植后存活了40天。微型细胞注射恢复了携带EL4的小鼠的巨噬细胞趋化活性，但未恢复淋巴细胞活性。
