Kurashige S, Yoshida T, Kodama K, Mitsuhashi S
Microbiol Immunol. 1981;25(5):467-77. doi: 10.1111/j.1348-0421.1981.tb00049.x.
Salmonella typhimurium strain 9 produces mini-cells during cell proliferation. Mini-cells are viable but cannot proliferate since they do not contain chromosomal DNA. Effects of whole cells and mini-cells of S. typhimurium on the immune responses were investigated, with the following results. Phagocytosis of peritoneal macrophages was enhanced by in vivo stimulation of both whole cells and mini-cells. Cellular immunity against L1210 cells (mouse leukemia cells) and Sarcoma 180 cells was also enhanced by both whole cells and mini-cells. Mini-cells slightly stimulated in vitro blast cell transformation of normal mouse lymphocytes. Whole cells of S. typhimurium induced antibody-forming cells to produce IgG of higher affinity but mini-cells did not. Mini-cells were not directly cytotoxic for normal lymphocytes or L1210 cells.
鼠伤寒沙门氏菌9型菌株在细胞增殖过程中产生微细胞。微细胞具有活力，但由于不含有染色体DNA，所以不能增殖。研究了鼠伤寒沙门氏菌全细胞和微细胞对免疫反应的影响，结果如下。全细胞和微细胞的体内刺激均可增强腹膜巨噬细胞的吞噬作用。全细胞和微细胞对L1210细胞（小鼠白血病细胞）和肉瘤180细胞的细胞免疫也有增强作用。微细胞对正常小鼠淋巴细胞的体外母细胞转化有轻微刺激作用。鼠伤寒沙门氏菌全细胞诱导抗体形成细胞产生亲和力更高的IgG，但微细胞则不能。微细胞对正常淋巴细胞或L1210细胞无直接细胞毒性。
