一株单细胞绿藻——普通小球藻对抗肿瘤抗性的增强作用。
Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris.
作者信息
Tanaka K, Konishi F, Himeno K, Taniguchi K, Nomoto K
出版信息
Cancer Immunol Immunother. 1984;17(2):90-4. doi: 10.1007/BF00200042.
Abstract
Growth of Meth-A tumor in CDF1 mice was inhibited significantly by injection of a hot water extract of a strain of Chlorella vulgaris (CE) into the tumor or into the subcutaneous tissue near the tumor. The augmentation of resistance by CE may require the participation of T cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. Mice treated with CE exhibited antigen-specific augmented resistance against rechallenge with tumor. Moreover, the antitumor effect of CE was comparable with that of Corynebacterium parvum, but its mechanism of effect might be different.
摘要
将普通小球藻（CE）菌株的热水提取物注射到CDF1小鼠的肿瘤内或肿瘤附近的皮下组织中，可显著抑制Meth-A肿瘤的生长。CE增强抵抗力可能需要T细胞和巨噬细胞的参与，因为在无胸腺裸鼠或用角叉菜胶（一种巨噬细胞阻滞剂）处理的小鼠中，这种增强作用被消除或减弱。用CE处理的小鼠对肿瘤再次攻击表现出抗原特异性增强的抵抗力。此外，CE的抗肿瘤作用与短小棒状杆菌相当，但其作用机制可能不同。
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