Kurashige S, Mitsuhashi S
Cancer Immunol Immunother. 1982;14(1):1-3. doi: 10.1007/BF00199423.
The enhancing effect of mini-cells of Salmonella typhimurium which do not contain chromosomal DNA on anti-tumor immunity in mice was studied. The growth of sarcoma 180 cells which were subcutaneously transplanted into ICR mice was significantly retarded in mice treated with Salmonella mini-cells at the same time or 7 days after S180 transplantation, while no or only a little growth inhibition was observed in mice treated 7 days prior to S180 transplantation. Treatment with mini-cells inoculation alone did not increase the survival time of mice that had received intraperitoneal transplants of S180 cells. However, a statistically significant increase of survival time was observed in mice treated with a combination of mini-cells and surgical resection of subcutaneous tumors when S180 cells were injected 7 days after the surgical resection. The injection of mini-cells restored macrophage chemotaxis in S180-bearing mice in which macrophage chemotaxis was greatly retarded but lymphocyte activity was not.
研究了不含染色体DNA的鼠伤寒沙门氏菌微小细胞对小鼠抗肿瘤免疫的增强作用。将肉瘤180细胞皮下移植到ICR小鼠体内，在同时用沙门氏菌微小细胞处理的小鼠中，或在S180移植后7天处理的小鼠中，肉瘤180细胞的生长明显受到抑制，而在S180移植前7天处理的小鼠中未观察到生长抑制或仅观察到轻微的生长抑制。单独接种微小细胞并不能延长接受S180细胞腹腔移植的小鼠的存活时间。然而，当在手术切除皮下肿瘤7天后注射S180细胞时，用微小细胞和皮下肿瘤手术切除联合处理的小鼠的存活时间有统计学意义的增加。注射微小细胞可恢复携带S180的小鼠中的巨噬细胞趋化性，在这些小鼠中巨噬细胞趋化性大大降低，但淋巴细胞活性未受影响。
