神经性贪食症中的神经内分泌异常。

Neuroendocrine abnormalities in bulimia.

作者信息

Gwirtsman H E, Roy-Byrne P, Yager J, Gerner R H

出版信息

Am J Psychiatry. 1983 May;140(5):559-63. doi: 10.1176/ajp.140.5.559.

DOI:10.1176/ajp.140.5.559

Abstract

The authors examined the relationship of clinical variables, family history, and neuroendocrine function in 18 bulimic patients. Twelve of 18 patients (67%) showed abnormalities of cortisol suppression, and 8 of 10 (80%) showed blunted thyrotropin-releasing hormone (TRH) tests. These findings suggest that neuroendocrine abnormalities identified previously in anorexia nervosa are not solely an artifact of low weight and, further, that eating disorders and affective disorders may share neurochemical similarities.

摘要

作者研究了18名贪食症患者的临床变量、家族史和神经内分泌功能之间的关系。18名患者中有12名（67%）表现出皮质醇抑制异常，10名中有8名（80%）表现出促甲状腺激素释放激素（TRH）试验反应迟钝。这些发现表明，先前在神经性厌食症中发现的神经内分泌异常并非仅仅是体重过低的假象，而且，饮食失调和情感障碍可能在神经化学方面存在相似之处。