囊性纤维化患者的血清胰脂肪酶活性
Serum pancreatic lipase activity in cystic fibrosis.
作者信息
Junglee D, Penketh A, Katrak A, Hodson M E, Batten J C, Dandona P
出版信息
Br Med J (Clin Res Ed). 1983 May 28;286(6379):1693-4. doi: 10.1136/bmj.286.6379.1693.
Patients with cystic fibrosis have been found to have abnormal serum concentrations of immunoreactive trypsin and abnormal activities of pancreatic isoamylase. A study was undertaken to discover whether activity of pancreatic lipase is also altered in cystic fibrosis. Serum from 23 patients with cystic fibrosis was assayed for immunoreactive trypsin and pancreatic lipase. Median serum pancreatic lipase activity was significantly lower in patients with cystic fibrosis than in controls, as was immunoreactive trypsin concentration (p less than 0.0001). Some patients had supranormal lipase concentrations but these were not always associated with absence of malabsorption. Serum pancreatic lipase activity is considerably changed in cystic fibrosis.
已发现囊性纤维化患者的免疫反应性胰蛋白酶血清浓度异常，且胰腺异淀粉酶活性异常。开展了一项研究，以探究囊性纤维化患者的胰腺脂肪酶活性是否也发生改变。对23例囊性纤维化患者的血清进行了免疫反应性胰蛋白酶和胰腺脂肪酶检测。囊性纤维化患者的血清胰腺脂肪酶活性中位数显著低于对照组，免疫反应性胰蛋白酶浓度也是如此（p<0.0001）。一些患者的脂肪酶浓度高于正常水平，但这些情况并不总是与不存在吸收不良相关。囊性纤维化患者的血清胰腺脂肪酶活性有显著变化。
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