胰岛素依赖型糖尿病患者胰脂肪酶水平低。
Low pancreatic lipase in insulin-dependent diabetics.
作者信息
Junglee D, De Albarran R, Katrak A, Freedman D B, Beckett A G, Dandona P
出版信息
J Clin Pathol. 1983 Feb;36(2):200-2. doi: 10.1136/jcp.36.2.200.
Serum samples obtained from 20 insulin-dependent diabetics (IDD), 23 non-insulin-dependent diabetics (NIDD) and 30 controls were assayed for their pancreatic lipase activity, immunoreactive trypsin concentration and glycosylated haemoglobin (HbA1) respectively. The distribution of serum pancreatic lipase activity in normal subjects and diabetics was nonparametric. The median serum lipase activity in IDDs (86 U/l) was significantly lower that that in controls (131 U/l, p less than 0.002) and NIDDs (126 U/l, p less than 0.001). There was a significant correlation between serum pancreatic lipase activity and serum IRT concentration (r = 0.65, p less than 0.001). Neither pancreatic lipase activity nor IRT was related to HbA1 concentrations. These data show for the first time that serum pancreatic lipase activity is diminished in IDDs.
分别对从20名胰岛素依赖型糖尿病患者（IDD）、23名非胰岛素依赖型糖尿病患者（NIDD）和30名对照者身上采集的血清样本进行了胰脂肪酶活性、免疫反应性胰蛋白酶浓度和糖化血红蛋白（HbA1）的检测。正常人和糖尿病患者血清胰脂肪酶活性的分布呈非参数性。IDD患者血清脂肪酶活性中位数（86 U/l）显著低于对照组（131 U/l，p<0.002）和NIDD患者（126 U/l，p<0.001）。血清胰脂肪酶活性与血清IRT浓度之间存在显著相关性（r = 0.65，p<0.001）。胰脂肪酶活性和IRT均与HbA1浓度无关。这些数据首次表明，IDD患者血清胰脂肪酶活性降低。
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